Unique and Independent Roles for MLL in Adult Hematopoietic Stem Cells and Progenitors
نویسندگان
چکیده
منابع مشابه
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.
The Mixed Lineage Leukemia (MLL) gene is essential for embryonic hematopoietic stem cell (HSC) development, but its role during adult hematopoiesis is unknown. Using an inducible knockout model, we demonstrate that Mll is essential for the maintenance of adult HSCs and progenitors, with fatal bone marrow failure occurring within 3 weeks of Mll deletion. Mll-deficient cells are selectively lost ...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2007
ISSN: 1934-5909
DOI: 10.1016/j.stem.2007.05.019